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The preclinical evidence base is substantial
The CYP2D6 interaction between bupropion and vortioxetine was anticipated and quantified ahead of prescribing, which is why vortioxetine was started low
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Serious adverse events are rare at low doses and typically occur in patients with personal or family histories of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, conditions which require pre-treatment screening
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For instance, maintaining a healthy lifestyle, including proper nutrition, regular exercise, and stress management techniques, can reduce the frequency and severity of outbreaks
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