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14 and Supplementary Table 1)

These include complex biosynthetic pathways, instability and heterogeneity of metabolic intermediates, and modulation of bioactivity by tissue specificity and disease stage

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However, there are few data on NRF2 activation in microglia in human tissues or animal models of ALS, and NRF2 signaling has not yet been evaluated in oligodendrocytes, although this may be relevant in the case of ALS which also involves demyelination [316]

According to a study published in the Journal of Cancer Science and Therapy (2), glutathione shortage increases oxidative stress, which can lead to cancer

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