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The latter observed a progressive and region-dependent decrease in [ 18 F]UCB-H binding (and, by extension, a decrease in synaptic density) in epileptic animals, with significant differences between groups even before the onset of seizures

The treatment can last from 15 minutes to 1 hour, depending on the amount of nutrients needed

However, direct BDNF therapeutics face a fundamental challenge: the protein does not cross the blood-brain barrier

Cell (2018) 173(1):2051

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