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In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization ) events observed in participants randomized to retatrutide (pooled 9 mg and 12 mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82 (95.0% CI: 0.55 to 1.22)
Two things made it happen early
Effect of selenium status on thyroid disease Selenium deficiency has been associated with a number of adverse thyroid conditions, including hypothyroidism, subclinical hypothyroidism, enlarged thyroid ( Reference Derumeaux, Valeix and Castetbon 74 Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) , thyroid cancer ( Reference Schmutzler, Mentrup and Schomburg 67 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 Reference Lin, Kuo and Chiang 79 ) and AITD, including HT ( Reference Wu, Rayman and Lv 75 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) and GD ( Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 , Reference Bulow Pedersen, Knudsen and Carle 80 )
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This is why fatigue on semaglutide and GLP-1 fatigue are so common
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