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Methods A total of 100 overweight or obese women with PCOS diagnosed according to the Rotterdam criteria were randomly assigned to two groups: MET (1000 mg twice daily [BID] for 16 weeks) and combination therapy (COM) (1000 mg MET BID plus 1- mg semaglutide once weekly [QW] for 16 weeks)
Your first injection typically produces the strongest nausea response
Adverse events were reported in 73% to 94% of the treatment groups and in 70% of the placebo group
Hydration and balanced nutrition further support this process
Research suggests GIP activation may enhance fat oxidation and thermogenesis, contributing to energy expenditure beyond what GLP-1 achieves alone
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