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A typical titration schedule begins at 100mcg per dose administered subcutaneously, held constant for 710 days while baseline measurements are collected

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Specifically, researchers looked at the rate of discontinuation of the drugs due to adverse events compared to placebo groups and found higher rates of nausea, vomiting and diarrhea

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When combined with hyaluronic acid, collagen IV production increases by an impressive 25.4-fold