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The ligand-free GLP-1R and GCGR deform the PxxG motif in a manner similar to the agonist-bound structures, while the ligand-free GIPR prefers a moderately kinked TM6 that is significantly different from the fully active structures

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Cell Metab (2018) 27(1):101117.e5

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In this study, we show the role of FA metabolism in HUA-associated LVR