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ACSL4 catalyzes the binding of long-chain PUFAs, such as arachidonic acid (AA) and adrenic acid (AdA), to coenzyme A (CoA) [33], after which these products are re-esterified by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to form phospholipids [34]

Inclusion criteria consisted of male and female participants without child bearing ability either due to menopause, documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, or bilateral tubal ligation, as well as age of at least 18 years, a body mass index of 30, or a body mass index of 27 with the presence of hypertension or dyslipidemia [1]

Even though this is still significantly lower than what can be achieved through bariatric surgery (approximately 30-35% of total body weight loss), the effects of medication can no longer be refuted

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The researchers suggest that the decreased availability of D2 receptors in obese individuals may contribute to their behavior of overeating