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Common gastrointestinal side effects include: Nausea and vomiting Diarrhoea or constipation Abdominal pain and bloating Reduced appetite Indigestion These effects typically diminish as the body adjusts to the medication, usually within several weeks
Participants receiving Retatrutide at the 12 mg dose achieved average weight loss of 24.2% over 48 weeks
Patients should maintain open communication with both their endocrinologist (thyroid specialist) and PlexusDx provider about levothyroxine dosing, TSH targets, and any symptoms of under- or over-replacement during GLP-1 initiation
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Annu Rev Biochem 52 : 711760
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