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The non-randomized trial by Pettegrew et al 12 assessed with ROBINS-I, showed a critical risk of bias from confounding and serious risk from participant selection, although other domains were low risk
J Am Coll Cardiol (2020) 75(16):195674
Limitations Direct trial evidence is in HIV-associated populations
There have also been other efforts to understand adipose tissue lipolysis in more detail, for example experimentally in [10] and using mathematical modelling in [11, 12], but without detailed intracellular components
Animal studies have shown thyroid C-cell tumours with semaglutide, though the relevance to humans is unknown
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