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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

Over 100 years ago, physicians experimented with TPEs potential to increase lifespan when the first recorded plasma exchange procedure was performed on animals

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Intermediate users may increase the dose to 400500 micrograms daily