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Scand J Clin Lab Invest Suppl
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
L., Zhu, X
Alternatives: Consider using unsweetened almond milk, oat milk, or a splash of low-fat dairy
Mori, K., Nagao, H
Elucidating the detailed mechanisms of Gq signaling in insulin and GLP-1 secretions may contribute to the development of new treatment strategies for diabetes
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