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The STEP 1 trial reported an average body-weight reduction of 14.9% with branded injectable semaglutide 2.4 mg over 68 weeks

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doi:10.1016/j.maturitas.2012.02.002 Masi CM, Hawkley LC, Berry JD, Cacioppo JT

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Therefore, we speculate that applying incretin-based medications in PD models can promote insulin secretion, improve peripheral and central insulin resistance, stabilize mitochondrial function, enhance energy metabolism, and exert neuroprotective effects that stabilize dopamine homeostasis (88)