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A 2023 SELECT trial determined that patients with pre-existing cardiovascular disease who used Wegovy over 39.8 months experienced the following events, compared to patients given a placebo

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Adverse events were mostly mild-to-moderate gastrointestinal symptoms, consistent with other incretin-based therapies

M1 macrophages exhibit dysregulated iron metabolism, with increased expression of hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL), and reduced expression of ferroportin (FPN) and IRP1/2 (88)