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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels
For example, because of Ozempics boxed warning for thyroid cancer, the drug is contraindicated for people with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
An agonist increases the effect of something (as opposed to an ant agonist, which inhibits an effect)
For instance, a 2020 review in the American Journal of Clinical Nutrition found that higher-fat dairy is associated with lower amounts of body fat in children
Anderson MP, Hooker BS, Herbert MR
This was true for semaglutide and liraglutide, among others
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