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However, there is a risk of localized infection or irritation at the injection site if the medication has become contaminated
Persistent nausea, vomiting, or constipation that doesn't improve with dose titration and lifestyle changes may resolve when switching to a medication with a different pharmacological profile
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Coskun and colleagues (Molecular Metabolism, 2018) reported the foundational characterisation: tirzepatide binds the human GIP receptor with Ki 0.135 nM and the human GLP-1 receptor with Ki 4.7 nM
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