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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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BME, WM, MSM, PC, BO, RL and CG: Participated in the recovery of blood samples and carried out the biochemistry determinations

The standard evaluative statement is this: preclinical evidence across multiple rodent models is consistently favorable

Important context: "GLP-3" is not a formal scientific or pharmacological designation

A., Goncalves, O