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To confirm whether an increase in UCK2 activity as a result of pyrimidine stress was the driving force behind mitochondrial biogenesis signalling, we knocked down UCK2 in cells using siRNA (Fig

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10.1016/j.ijpharm.2019.118642 120 ZhongJ.AghaG.BaccarelliA

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Participants describe feeling full after consuming smaller amounts of food and experiencing reduced desire to eat between meals