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The Leyden 2002 clinical evaluation in the Journal of Cosmetic Dermatology compared a copper tripeptide cream and serum against placebo in 67 women with photodamaged skin and found significant improvements in wrinkle depth, skin laxity, clarity, and density at 12 weeks [30]

Compliance: Adhere to the recommended treatment plan and schedule provided by your healthcare provider

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Moreover, the skin's ability to retain water depends on several factors beyond simple hydration