A 2014 review suggests that in patients with liver disease, BCAA supplements may be more beneficial than other supplements at reducing the severity of HE ( However, BCAAs did not improve overall survival rate, and they didnt lower the risk of other complications, such as infections and gastric bleeding ( Another review of studies in patients undergoing liver surgery reported that BCAA-enriched solutions may help improve liver function, reduce the risk of complications, and decrease the duration of hospital stay ( BCAA supplements may also be effective at reducing fatigue and improving weakness, sleep quality, and muscle cramps in individuals with liver disease ( In cases of liver cancer, taking BCAA supplements may help reduce water retention and decrease the risk of premature death ( However, if you have liver disease, please speak with your healthcare team about using BCAA supplements before starting them
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While its not confirmed in humans, its a potential risk that needs monitoring
Presented for research literature review only Petrick HL et al
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In the recently published SURMOUNT-5 trial, which evaluated weight reduction over 72 weeks with the maximum tolerated dose of tirzepatide (10 or 15 mg) vs semaglutide (1.7 or 2.4 mg) in adults with obesity without type 2 diabetes, tirzepatide showed superior efficacy