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The positive outcomes of agents like canakinumab and colchicine suggest that effective strategies must precisely target the key nodessuch as the IL-1 pathway or the NLRP3 inflammasomethat directly perpetuate the vicious cycle between oxidative stress and inflammation detailed in Section 2.4.1

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GEP44 is linked to high-energy expenditure, which takes the form of increased movement, heart rate or body temperature, says Doyle, Deans Professor of Chemistry in the College of Arts and Sciences