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These long-term exposures have been associated with a variety of systemic effects (mycotoxicoses) in both humans and animals and most commonly manifest as nephrotoxicity, hepatotoxicity, immunosuppression, carcinogenicity, and teratogenicity
Furthermore, these genes have been found to play a role in pneumococcal pathogenesis, as mutants lacking these genes exhibited reduced virulence in a mouse model of infection (Potter et al., 2012)
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