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As the key enzyme metabolizing APAP into NAPQI, cytochrome P450 enzymes are also considered to be intriguing target for the treatment of APAP-induced liver injury

Further human studies are required to substantiate the claims

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The UPR response involves three signaling pathways, namely the protein kinase RNA-like ER kinase (PERK), inositol requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6) signaling pathways [25]

Because healthy, dividing cells rely far less on the FOXO4p53 survival mechanism, the idea is that theyre largely spared