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CJC-1295 without DAC 5mg + IPA 5mg Tier Product description What is CJC-1295 without DAC 5mg + IPA 5mg
Li T, Huang M, Lu J
Individuals 60 years and older have lower plasma GSH levels and increased oxidative stress (Samiec et al., 1998)
Polyphenols face significant bioavailability bottlenecks when administered orally, and their pharmacokinetic properties make it difficult to reach therapeutic window concentrations in inner ear hair cells and auditory nerves (Osakabe et al., 2023), a limitation that significantly restricts their potential application in the prevention and treatment of CIO.However, reactive oxygen species present a dual role in the pathological process of CIO: as a key pathogenic factor mediating cisplatin ototoxicity and as a pharmacological basis for its tumor cell-killing effects, and this paradoxical property makes the construction of an inner-ear-targeted delivery system a central challenge for synergistic chemotherapy with polyphenolic compounds
[Available from: Essigmann JM, Barker LJ, Fowler KW, Francisco MA, Reinhold VN, Wogan GN
