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Almost from the introduction of this family of drugs, anesthesia providers were aware of delayed gastric emptying and the increased risk for aspiration

Journal of Medicinal Chemistry , 66 (16), 1139011398

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10.2147/VHRM.S484638 159

Concomitant use with coumarin anticoagulants such as warfarin has been associated with elevations in the international normalized ratio, requiring closer INR surveillance and potential dose adjustment

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