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Significant weight loss from GLP-1 therapy may require levothyroxine dose adjustments, as thyroid hormone needs are partially determined by body weight

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Anyhow, according to our preclinical data, GLP1/E may be superior in terms of metabolic handling in women with PCOS and obesity not actively seeking pregnancy, as reflected by our results in the metabolically-compromised PWA mice 36

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Oral antidiabetic medication was discontinued 3 weeks prior to the study