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But, how often depends on how bad the deficiency is and how well theyre doing

If you begin to experience symptoms of pernicious anemia after reducing your daily injection to a weekly or monthly shot, you may be advised to resume maintaining the habit of taking one shot each day, until your body achieves a more stable result

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[29] [30] Other supplements taken alongside B12, particularly magnesium, vitamin C in high doses, or probiotic preparations, may affect bowel habits

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Clinical trials tested doses ranging from 250mcg to 1mg daily, with most protocols settling around 300-500mcg for optimal fat metabolism support