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Weight loss can include both fat mass and lean mass, which is why protein intake and resistance training are often discussed alongside GLP-1 use
Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure
Semaglutide and the other GLP-1 agonists have the added benefit of central effects on the hunger centres in the hypothalamus as well as delaying gastric emptying to increase fullness and suppress appetite, a valuable tool for both the treatment of diabetes and weight loss management, but a potential risk for the use of sedation/anaesthesia
If the new discounted price applies only to select doses it would lessen overall savings for plan sponsors as the discounts would apply to a limited subset of utilizers
Are GLP-1 Drugs Safe
& Ravussin, E
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