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7.1 Identification of gutliver axisrelated therapeutic targets The future studies to systematically identify key molecular targets involved in gutliver communication during cadmium exposure, including intestinal barrier regulators, bile acid signaling pathways, microbial metabolites, and inflammatory mediators, which may serve as potential intervention targets

Activated macrophages elevate cytotoxic molecules, such as free radical species and proinflammatory cytokines, which contribute to neurotoxicity in coculture systems 34,41 and in a murine model 42

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