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Most available research is based on small, short-term human studies, animal models, or lab experiments not large-scale clinical trials

Normalization of fasting hyperglycaemia by exogenous glucagon- like peptide 1 (736 amide) in type 2 (non-insulin-dependent) diabetic patients

For example, researchers are studying its effect on cardiovascular and kidney outcomes for patients with obesity

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While this does not prove that melatonin causes heart failure, it does highlight the need for caution with prolonged, nightly use

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