That decline is a large part of why glutathione has become a target for supplementation the premise is to restore a molecule the body makes less of over time
PMID: 38432109 PLoS Genet A C
The animal models behave normally without signs for pain, stress, or discomfort
And it is very effective
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A practical way to read the two cadences together: the weekly 5-on/2-off rhythm is a fine-grained pause aimed at short-term receptor sensitivity, while the 812-on / 4-off macro-cycle is the coarse-grained pause aimed at the whole axis