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There was no elevated risk of birth defects in pregnancies exposed to GLP-1s

As with any weight loss treatment, focusing on long-term, sustainable lifestyle changes is crucial to achieving lasting results

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Clinically reviewed by: Priscilla Rodriguez, MHA, RN Last updated: December 2025 Many people start GLP-1 medications wondering what comes next

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However, if you have been at maximum dose for 12 or more weeks without adequate response, or if side effects prevent further dose increases, switching to tirzepatide is a reasonable next step