Moreover, it is now recognized that any cause of mucosal cell apoptosis can lead to this pigmentation, such as NSAIDs and IBD, which can also induce epithelial cell apoptosis.25 Some researchers have found that anthraquinone laxatives are decomposed by bacteria that consequently produce a type of rhubarb derivative in the caecum.26 The rhubarb derivative damages the intestinal epithelial cells and then promotes the effects of the laxative but then can lead to death of these cells, which are immediately engulfed by nearby macrophages
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These mechanisms are implicated in the neurobiology of BD, and preliminary findings suggest benefits across core psychopathological domains and common comorbidities, including depression, anxiety, mania, cognitive dysfunction, weight gain, and substance use disorders
Cell Metab 2019;29:681-94.ArticlePubMed 98
48 Similar results were obtained in a hGLP-1R knock-in murine model in which the administration of Danuglipron resulted in an overall improvement of glucose tolerance and food intake reduction, thus opening the possibility to use an effective oral GLP-1RA
