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AFB1 exposure in mice and rats revealed the memory and learning deficits, motor function decline, anxious-depressive-like behavior with an increase of acetylcholinesterase (AChE) activity in the brain and monoamine oxidase, and a reduction of antioxidant system markers [54,56,57]

The metabolite biomarkers discovered through this process could be used as biomarkers for the diagnosis of MDD and remission status, irrespective of exposure to drug treatment, including antidepressants

Glu170 is too far away from the active site to directly affect the interaction between HEDS and the cysteine thiolate

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However, prolonged gastric retention also means delayed arrival at the intrinsic factor binding sites and the ileal absorption receptors