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NCI Dictionary of Cancer Terms [Internet]

Based on current clinical trial data, tirzepatide (Zepbound/Mounjaro) at the 15 mg dose produces the highest average weight loss approximately 2022% of body weight, or around 48 lbs on average in the SURMOUNT-1 trial

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Because insulin release is glucose-dependent, GLP-1 promotes insulin mainly when blood sugar is elevated, which is part of why the pathway is so attractive as a therapeutic target