Semaglutide Insomnia: Why You Feel "Wired" & How to Fix It Share Key Takeaways The Cause: GLP-1 medications may stimulate the Orexin ("alertness") pathway, creating a "wired" sensation
PlexusDx Microdose GLP-1 Protocol ($129/month flat) offers a gentler entry point for patients prone to GI side effects, using lower initial doses that escalate more gradually
Comprehensive lab work is the non-negotiable first step for both safety and effectiveness
GLP-1 helps regulate blood sugar, reduce appetite, and slow gastric emptying
Scientific References Sitagliptin 25 mg film-coated tablets Summary of Product Characteristics (emc product 14095)
Ro program includes registered nurse support, an education curriculum covering nutrition, exercise, sleep, and lifestyle change, and an insurance concierge service