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Randomized trials that isolated B12 tend to be small or combine the vitamin with other agents, making causal claims weak
Some neurological symptoms may continue improving for up to 1218 months, though permanent damage can occur if deficiency was severe and prolonged
Initial signs of response typically appear by week 3-4, with meaningful results developing through weeks 5-8
Induction of glutathione S-transferase activity by curcumin in mice [PMID: 1418063] Laboratory literature summary: Induction of glutathione S-transferase activity by curcumin in mice
Most current users inject AOD-9604 rather than taking it orally, so the trial data may underestimate what injectable protocols achieve
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