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When combined with GLP-1 receptor agonism, GIP activity appears to amplify weight loss and glycaemic benefits, as suggested by tirzepatide's clinical profile (NICE TA943)

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Additionally, some atypical antipsychotics used for treatment-resistant depression (such as quetiapine or olanzapine) carry a high risk of metabolic syndrome, weight gain, and hyperglycaemia, as noted in NICE guidance

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