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Dosage and administration Typical protocols in the literature and clinical practice use subcutaneous injection , often run in a loading-then-maintenance pattern: a higher loading dose over the first 46 weeks, then a lower maintenance dose

Large amounts of alcohol irritate the mucosal linings in the stomach and intestines leading to a condition called gastritis which further leads to reduced absorption of B12 levels in the body

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Many of these have only early-stage or animal data behind them and do not have marketing authorisation in the UK, meaning they are effectively unlicensed medicines

However, people with normal intestinal absorption and mild to moderate B12 deficiency symptoms can take oral B12 supplementation (B12 and folic acid pills)

Nevertheless, this guide has illuminated key areas where further TB-500 investigation may be warranted, providing researchers with a useful starting point for future studies