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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

One study found that high doses of oral B12 (1,000 mcg daily) could provide adequate absorption even in the presence of intrinsic factor deficiency

B12 injections typically deliver about 1,000 mcg per dose, while oral supplements can range from 50 to 5,000 mcg

Additionally, the absorption rate of subcutaneous injection is slower compared to intramuscular and intravenous

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