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If sleep quality deteriorates, dose timing or total daily dose may need adjustment

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Multiple studies have shown elevated levels of cytokine in peripheral blood of children with ASD

Serum EGF, for example, was significantly higher in hepatocellular carcinoma than in hepatitis Crelated cirrhosis, supporting its use in hepatocellular carcinoma diagnosis, prognosis, and recurrence monitoring 184

Serious safety concerns are rare but include: Systemic infections : Immunocompromised individuals, those with central venous catheters, or patients with damaged gut barriers face increased risk of bacteremia or fungemia from probiotic organisms [19] [20] Antibiotic resistance transfer : Some probiotic strains may carry antibiotic resistance genes Metabolic complications : Rare cases of D-lactic acidosis have been reported with high-dose probiotic use [25] Specific populations requiring caution include patients with severe acute pancreatitis (based on the PROPATRIA trial showing increased mortality), short bowel syndrome, immunosuppression (HIV/AIDS, chemotherapy, organ transplant recipients), and critically ill individuals

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