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Similarly, in pancreatic ductal adenocarcinoma (PDAC) and NALM-6 leukemia cells, membrane lipid remodeling involving polyunsaturated fatty acidcholesterol esters (PUFA-CEs)generated via the acyl-CoA synthetase long-chain family member 4 (ACSL4)sterol o-acyltransferase 1 (SOAT1) pathway and regulated by solute carrier family 47 member 1 (SLC47A1)drives ferroptotic sensitivity [59]
Conflict of interest Author AK was employed by Nasco AD Biotechnology Laboratory
B12 is essential for red blood cell production and DNA synthesis both crucial for healthy hair follicle function
For example, puerarin has been approved for use in treating cardiovascular diseases, while kaempferide and kaempferol can scavenge free radicals and thereby inhibit ferroptosis [121, 122]
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These factors make drug development a very challenging task
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