The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research
The few who are not, are those who have pacemakers (AICDs), and those who have had dermal fillers in the treatment area (under the eye) within the past 2 weeks
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However, if a specialized laboratory test is used, stable metabolites of the peptide can typically be detected for roughly 24 to 48 hours after administration, with some studies suggesting trace detection up to 4 days later
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Chitosan on the surface of nanoparticles for enhanced drug delivery: a comprehensive review