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When ROS accumulation exceeds cellular detoxification capacity, oxidative damage to lipids, proteins, and nucleic acids occurs, potentially culminating in severe photoinhibition and the activation of programmed cell death pathways

Unfortunately, we lost 3 rats and data was calculated for 14 animals (and for 1 animal for 3 data points)

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PMID: 6291585

Grx gene silencing in hepatocytes further sensitized hepatocytes to TNF-mediated killing