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It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes

Expert Opinion on Biological Therapy 12(1):37-51

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It was suggested that the differentiated production of IL-1 and IL-8 may be linked to the type of product applied, either an irritant or a sensitizer 39,40

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Both approaches are preferable to pushing through severe symptoms