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The Cochrane Collaboration, Chichester, UK: John Wiley & Sons
All products are supplied for research use only (RUO) and are not intended for human consumption
There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]
For medical use, see Cyanocobalamin injection for adverse effects and precautions
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So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load
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