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Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology
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Lactate uptake by CD4 + T cells has been implicated in inhibiting migratory capability, essentially arresting T cells in the lactate hi microenvironment ( Figure 1 )
Glutathione helps protect brain cells from damage, supports healthy energy production, aids detoxification and helps maintain the resilience of cells as we age
Chen Y, Zhou K, Wang R et al (2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimers amyloid peptides via up-regulating BACE1 transcription
& Salvatore, C
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