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Across the studied peptides, the authors reported reduced MMP-9 synthesis, increased Ki-67 and CD98hc expression, and, for AED and AEDG, suppression of caspase-dependent apoptosis that increased during cell-culture aging

10.1038/jid.2008.410 33 DeBose-BoydR

Copper is also used in superoxide dismutase, an enzyme that handles oxidative stress, and oxidative stress is one driver of fine lines and dull tone after years of UV exposure

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Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress