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However, there are signaling molecules in the extracellular space of RGCs that could prevent the regeneration of RGCs (183)

After 8 weeks, the treatment group showed a 20% increase in hydration levels, measured by corneometry, and improved epidermal and dermal thickness due to enhanced glycosaminoglycan synthesis (Krger et al., 2010)

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Topical anti-aging effects are biologically plausible because collagen, glycosaminoglycans, skin elasticity, fibroblasts, and extracellular matrix remodeling are all directly relevant to skin aging [2], [4], [12]