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The trial focused on treating obesity, showing an average weight loss of 17.5% at 24 weeks and 24.2% at 48 weeks at the highest dosage prescribed for adults with obesity and overweight
Interestingly, the authors revealed that the dose of exendin-4 at 10 nmol/kg for 4 weeks had no effect on blood glucose, body weight, or HbA1c levels in streptozotocin-induced DM mice
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In summary, MTs could have a significant impact on diabetes prevention by mitigating hyperglycemia-induced oxidative stress as they safeguard pancreatic -cells against damage from free radicals and maintain regular insulin secretion [115, 116]